Chemist Ted Sallis was assigned to "Project Gladiator," an experiment aimed at the lost "super-soldier" serum that had spawned Captain America during World War II. Sallis attempted to modify the "super-soldier" serum with another serum, one that had historically transformed people into monsters and got close to success. But he was betrayed by his wife, Ellen. To guarantee that the secret would not fall into the wrong hands, Sallis injected himself with the only existing sample of his modified Super Soldier serum, and fled into the nearby swamp. Sallis should have died, but over the course of several hours, mystical forces combined with the chemical science to transform him into the monstrous, misshapen creature who would be dubbed the Man-Thing.

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